Tae Hwan Kim.Korean J Ophthalmol 2022

摘要

Purpose: To compare serum selenium levels in Graves patients and non-Graves control participants and to evaluate associations between serum selenium levels and clinical features of Graves orbitopathy (GO).

Methods: We conducted a single-center, retrospective case-control study among 33 patients with Graves disease without GO (GD), 31 patients with diagnosed GO, and 27 unaffected healthy participants enrolled between 2013 and 2020 at Severance Hospital. We compared serum selenium concentrations between the GD, GO, and healthy control groups, and analyzed associations between serum selenium and GO patients’ clinical activity scores, severity (assessed through modified NOSPECS scores), and other clinical features using multivariate linear regression analysis.

Results: Mean serum selenium levels were 109.30 ± 16.39, 111.39 ± 14.04, and 126.09 ± 21.09 ng/mL in GO patients, GD patients, and healthy control participants, respectively. Mean serum selenium levels in Graves patients with and without orbitopathy were significantly lower than those in the healthy control group (p < 0.05), and mean selenium levels were slightly lower in GO than those in GD patients (p = 0.594). Serum selenium levels were significantly lower in GO patients with eyelid retraction than in patients without retraction (p = 0.038). However, serum selenium levels were not associated with clinical activity scores and modified NOSPECS scores (p = 0.241 and 0.801, respectively).

Conclusions: Serum selenium levels were significantly lower in Graves patients with or without GO, compared to non-Graves control participants. Selenium levels were not associated with clinical activity scores or NOSPECS scores, though we observed an association with eyelid retraction.

目的：比较Graves患者和非Graves对照参与者的血清硒水平，并评估血清硒水平与Graves眼病（GO）临床特征之间的关系。
方法：我们对2013年至2020年在Severance医院登记的33名Graves病GO（GD）患者、31名确诊GO患者和27名未受影响的健康参与者进行了单中心回顾性病例对照研究。我们比较了GD、GO和健康对照组的血清硒浓度，并使用多元线性回归分析分析了血清硒与GO患者临床活动评分、严重程度（通过修改的NOSPECS评分评估）和其他临床特征之间的相关性。

结果：GO患者、GD患者和健康对照参与者的平均血清硒水平分别为109.30±16.39、111.39±14.04和126.09±21.09 ng/mL。患有和不患有眼病的Graves患者的平均血清硒水平显著低于健康对照组（p<0.05），GO患者的硒水平略低于GD患者（p=0.594）。有眼睑回缩的GO患者的血清硒水平明显低于无眼睑回撤的患者（p=0.038）。然而，血清硒水平与临床活动评分和改NOSPECS评分无关（分别为p=0.241和0.801）。
结论：与非Graves对照组相比，患有或不患有GO的Graves患者的血清硒水平显著降低。硒水平与临床活动评分或NOSPECS评分无关，但是我们观察到硒水平与眼睑回缩有关。

结果

GO患者的平均血清硒水平为109.30±16.39 ng/mL，GD患者为111.39±14.04 ng/mL，健康对照组为126.09±21.09 ng/mL。GD和GO患者的平均血清硒水平显著低于健康组（p<0.05）。